Software applications toward quantitative metabolic flux analysis and modeling
نویسندگان
چکیده
منابع مشابه
Software applications for flux balance analysis
Flux balance analysis (FBA) is a widely used computational method for characterizing and engineering intrinsic cellular metabolism. The increasing number of its successful applications and growing popularity are possibly attributable to the availability of specific software tools for FBA. Each tool has its unique features and limitations with respect to operational environment, user-interface a...
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New experimental data on metabolites and enzymes induce high interest in metabolic modelling including metabolic flux calculations. Data analysis of metabolites, calculation of metabolic fluxes, pathways and their conditionspecific strengths is now possible by an advantageous combination of specific software. How can available software for metabolic modelling be improved from a computational po...
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Small genome sequencing and annotations are leading to the definition of metabolic genotypes in an increasing number of organisms. Proteomics is beginning to give insights into the use of the metabolic genotype under given growth conditions. These data sets give the basis for systemically studying the genotype-phenotype relationship. Methods of systems science need to be employed to analyze, in...
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BACKGROUND The quantitative analysis of metabolic fluxes, i.e., in vivo activities of intracellular enzymes and pathways, provides key information on biological systems in systems biology and metabolic engineering. It is based on a comprehensive approach combining (i) tracer cultivation on 13C substrates, (ii) 13C labelling analysis by mass spectrometry and (iii) mathematical modelling for expe...
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ژورنال
عنوان ژورنال: Briefings in Bioinformatics
سال: 2012
ISSN: 1467-5463,1477-4054
DOI: 10.1093/bib/bbs065